Limitations of the C6/Wistar rat intracerebral glioma model: implications for evaluating immunotherapy
AT Parsa, I Chakrabarti, PT Hurley, JH Chi, JS Hall… - …, 2000 - journals.lww.com
OBJECTIVE: Intracranial rat glioma models are a useful method for evaluating the efficacy
and toxicity of novel therapies for malignant glioma. The C6/Wistar model has been used
extensively as a reproducible in vivo model for studying primary brain tumors including anti-
glioma immune responses. The objective of the present study is to provide in vivo evidence
that the C6 rat glioma model is allogeneic within Wistar rats and is therefore inappropriate
for evaluating immune responses. METHODS: Growth patterns and immune responses of …
and toxicity of novel therapies for malignant glioma. The C6/Wistar model has been used
extensively as a reproducible in vivo model for studying primary brain tumors including anti-
glioma immune responses. The objective of the present study is to provide in vivo evidence
that the C6 rat glioma model is allogeneic within Wistar rats and is therefore inappropriate
for evaluating immune responses. METHODS: Growth patterns and immune responses of …