T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

ML Dustin, TA Springer - Nature, 1989 - nature.com
Nature, 1989nature.com
Effective interaction between T cells and their targets requires that recognition of specific
antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor
cross-linking increases the strength of the adhesion mechan-ism between lymphocyte
function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with
intracellular signals trans-mitted from the T-cell antigen receptor to the LFA-1 adhesion
molecule. The increase in avidity is rapid and transient providing a dynamic mechanism for …
Abstract
Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechan-ism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals trans-mitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion.
nature.com