[HTML][HTML] ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the γ …
T Tousseyn, A Thathiah, E Jorissen… - Journal of Biological …, 2009 - ASBMB
ADAM10 is involved in the proteolytic processing and shedding of proteins such as the
amyloid precursor protein (APP), cadherins, and the Notch receptors, thereby initiating the
regulated intramembrane proteolysis (RIP) of these proteins. Here, we demonstrate that the
sheddase ADAM10 is also subject to RIP. We identify ADAM9 and-15 as the proteases
responsible for releasing the ADAM10 ectodomain, and Presenilin/γ-Secretase as the
protease responsible for the release of the ADAM10 intracellular domain (ICD). This domain …
amyloid precursor protein (APP), cadherins, and the Notch receptors, thereby initiating the
regulated intramembrane proteolysis (RIP) of these proteins. Here, we demonstrate that the
sheddase ADAM10 is also subject to RIP. We identify ADAM9 and-15 as the proteases
responsible for releasing the ADAM10 ectodomain, and Presenilin/γ-Secretase as the
protease responsible for the release of the ADAM10 intracellular domain (ICD). This domain …