Recent advances in the study of CD22 indicate a complex role for this transmembrane
glycoprotein member of the immunoglobulin superfamily in the regulation of B lymphocyte
survival and proliferation. CD22 has been previously recognized as a potential lectin‐like
adhesion molecule that binds α2, 6‐linked sialic acid‐bearing ligands and as an important
regulator of B‐cell antigen receptor (BCR) signaling. However, genetic studies in mice
reveal that some CD22 functions are regulated by ligand binding, whereas other functions …