PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

K Hasegawa, F Martin, G Huang, D Tumas, L Diehl… - Science, 2004 - science.org
K Hasegawa, F Martin, G Huang, D Tumas, L Diehl, AC Chan
Science, 2004science.org
Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell
function. We examined the role of PEST domain–enriched tyrosine phosphatase (PEP) in
regulating T cell antigen–receptor function during thymocyte development and peripheral T
cell differentiation. Although normal naïve T cell functions were retained in pep-deficient
mice, effector/memory T cells demonstrated enhanced activation of Lck. In turn, this resulted
in increased expansion and function of the effector/memory T cell pool, which was also …
Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell function. We examined the role of PEST domain–enriched tyrosine phosphatase (PEP) in regulating T cell antigen–receptor function during thymocyte development and peripheral T cell differentiation. Although normal naïve T cell functions were retained in pep-deficient mice, effector/memory T cells demonstrated enhanced activation of Lck. In turn, this resulted in increased expansion and function of the effector/memory T cell pool, which was also associated with spontaneous development of germinal centers and elevated serum antibody levels. These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function.
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