[HTML][HTML] Hypoglycemia reduces vascular endothelial growth factor a production by pancreatic beta cells as a regulator of beta cell mass
X Xiao, P Guo, Z Chen, Y El-Gohary, J Wiersch… - Journal of Biological …, 2013 - ASBMB
VEGF-A expression in beta cells is critical for pancreatic development, formation of islet-
specific vasculature, and Insulin secretion. However, two key questions remain. First, is
VEGF-A release from beta cells coupled to VEGF-A production in beta cells? Second, how is
the VEGF-A response by beta cells affected by metabolic signals? Here, we show that VEGF-
A secretion, but not gene transcription, in either cultured islets or purified pancreatic beta
cells, was significantly reduced early on during low glucose conditions. In vivo, a sustained …
specific vasculature, and Insulin secretion. However, two key questions remain. First, is
VEGF-A release from beta cells coupled to VEGF-A production in beta cells? Second, how is
the VEGF-A response by beta cells affected by metabolic signals? Here, we show that VEGF-
A secretion, but not gene transcription, in either cultured islets or purified pancreatic beta
cells, was significantly reduced early on during low glucose conditions. In vivo, a sustained …