Mechanisms of transplant tolerance induction using costimulatory blockade

T Wekerle, J Kurtz, S Bigenzahn, Y Takeuchi… - Current opinion in …, 2002 - Elsevier
T Wekerle, J Kurtz, S Bigenzahn, Y Takeuchi, M Sykes
Current opinion in immunology, 2002Elsevier
The potential use of costimulation-blocking reagents to induce transplantation tolerance has
recently created considerable excitement. Recent evidence has begun to delineate the
mechanisms by which these powerful effects occur. It has become increasingly clear, firstly,
that T cell costimulation is mediated by a delicate network of signaling pathways and,
secondly, that interference with these systems can lead to numerous different tolerance
mechanisms, including immune regulation, anergy and deletion.
The potential use of costimulation-blocking reagents to induce transplantation tolerance has recently created considerable excitement. Recent evidence has begun to delineate the mechanisms by which these powerful effects occur. It has become increasingly clear, firstly, that T cell costimulation is mediated by a delicate network of signaling pathways and, secondly, that interference with these systems can lead to numerous different tolerance mechanisms, including immune regulation, anergy and deletion.
Elsevier