IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy
Abstract Objectives Interleukin 33 (IL-33) is a new member of the IL-1 family of cytokines
which signals via its receptor, ST2 (IL-33R), and has an important role in Th2 and mast cell
responses. This study shows that IL-33 orchestrates neutrophil migration in arthritis.
Methods and results Methylated bovine serum albumin (mBSA) challenge in the knee joint
of mBSA-immunised mice induced local neutrophil migration accompanied by increased IL-
33R and IL-33 mRNA expression. Cell migration was inhibited by systemic and local …
which signals via its receptor, ST2 (IL-33R), and has an important role in Th2 and mast cell
responses. This study shows that IL-33 orchestrates neutrophil migration in arthritis.
Methods and results Methylated bovine serum albumin (mBSA) challenge in the knee joint
of mBSA-immunised mice induced local neutrophil migration accompanied by increased IL-
33R and IL-33 mRNA expression. Cell migration was inhibited by systemic and local …