[HTML][HTML] Sestrins at the crossroad between stress and aging
Sestrins are a family of stress-inducible proteins that can function as antioxidants and as
inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the
possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can
result in premature aging and age-related diseases. We suggest that Sestrins provide critical
feedback regulation that adjust metabolic and stress responses to different environmental
cues and evolutionary constraints.
inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the
possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can
result in premature aging and age-related diseases. We suggest that Sestrins provide critical
feedback regulation that adjust metabolic and stress responses to different environmental
cues and evolutionary constraints.
Abstract
Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.
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