[HTML][HTML] Sestrins at the crossroad between stress and aging

JH Lee, R Bodmer, E Bier, M Karin - Aging (Albany NY), 2010 - ncbi.nlm.nih.gov
Aging (Albany NY), 2010ncbi.nlm.nih.gov
Sestrins are a family of stress-inducible proteins that can function as antioxidants and as
inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the
possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can
result in premature aging and age-related diseases. We suggest that Sestrins provide critical
feedback regulation that adjust metabolic and stress responses to different environmental
cues and evolutionary constraints.
Abstract
Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.
ncbi.nlm.nih.gov