The mammalian target of rapamycin (mTOR) protein kinase responds to diverse
environmental cues to control a plethora of cellular processes. mTOR forms the catalytic
core of at least two distinct signaling complexes known as mTOR complexes 1 and 2.
Differing sensitivities to the mTOR inhibitor rapamycin, unique partner proteins, distinct
substrates, and unique cellular functions distinguish the complexes. Here, we review recent
progress in our understanding of the regulation and function of mTOR signaling networks in …