[CITATION][C] VLA proteins in the integrin family: structures, functions, and their role on leukocytes
ME Hemler - Annual review of immunology, 1990 - annualreviews.org
Multiple receptor systems mediate a variety of leukocyte adhesion capa bilities. For
example, the T cell receptor is utilized for specific adhesion of T lymphocytes to cells bearing
foreign antigen plus MHC (I), and other cell-cell interaction molecules such as CD2 and LFA-
3 augment these antigen-specific interactions (2). To facilitate tissue-specific migration and
recirculation of lymphocytes through lymphoid organs, at least two dis tinct proteins, MEL-14
(3) and gp90/CD44 (4), have evolved to function as homing receptors, and additional …
example, the T cell receptor is utilized for specific adhesion of T lymphocytes to cells bearing
foreign antigen plus MHC (I), and other cell-cell interaction molecules such as CD2 and LFA-
3 augment these antigen-specific interactions (2). To facilitate tissue-specific migration and
recirculation of lymphocytes through lymphoid organs, at least two dis tinct proteins, MEL-14
(3) and gp90/CD44 (4), have evolved to function as homing receptors, and additional …