[HTML][HTML] Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development
Nestin is a molecular marker for neural progenitor cells. Rat and human nestin genes
possess a central nervous system-specific enhancer within their second introns. However,
the transcription factors that bind to the nestin enhancer have not been fully elucidated.
Here, we show that the second intron of the mouse nestin gene is sufficient to drive reporter
gene expression in the developing nervous system. The core sequence of this central
nervous system-specific enhancer localizes to the 3′ 320-bp region. The cis-elements for …
possess a central nervous system-specific enhancer within their second introns. However,
the transcription factors that bind to the nestin enhancer have not been fully elucidated.
Here, we show that the second intron of the mouse nestin gene is sufficient to drive reporter
gene expression in the developing nervous system. The core sequence of this central
nervous system-specific enhancer localizes to the 3′ 320-bp region. The cis-elements for …