Behavioral and anatomical abnormalities in a sodium iodate-induced model of retinal pigment epithelium degeneration

V Enzmann, BW Row, Y Yamauchi… - Experimental eye …, 2006 - Elsevier
We characterized changes in the visual behavior of mice in which a loss of the retinal
pigment epithelium (RPE) was experimentally induced with intravenous (iv) administration of
sodium iodate (NaIO3). We compared and correlated these changes with alterations in
neural retinal structure and function. RPE loss was induced in 4–6 week old male C57BL/6
mice with an iv injection of 1% NaIO3 at three concentrations: 35, 50, or 70mg/kg. At 1, 3, 7,
14, 21, and 28 days (d) as well as 6 months post injection (PI) a behavioral test was …