T lymphocyte–endothelial cell interactions
J Choi, DR Enis, KP Koh, SL Shiao… - Annu. Rev. Immunol …, 2004 - annualreviews.org
▪ Abstract Human vascular endothelial cells (EC) basally display class I and II MHC-peptide
complexes on their surface and come in regular contact with circulating T cells. We propose
that EC present microbial antigens to memory T cells as a mechanism of immune
surveillance. Activated T cells, in turn, provide both soluble and contact-dependant signals
to modulate normal EC functions, including formation and remodeling of blood vessels,
regulation of blood flow, regulation of blood fluidity, maintenance of permselectivity …
complexes on their surface and come in regular contact with circulating T cells. We propose
that EC present microbial antigens to memory T cells as a mechanism of immune
surveillance. Activated T cells, in turn, provide both soluble and contact-dependant signals
to modulate normal EC functions, including formation and remodeling of blood vessels,
regulation of blood flow, regulation of blood fluidity, maintenance of permselectivity …