[HTML][HTML] Membrane-impermeable Cross-linking Provides Evidence for Homophilic, Isoform-specific Binding of Desmosomal Cadherins in Epithelial Cells*♦
Z Nie, A Merritt, M Rouhi-Parkouhi, L Tabernero… - Journal of biological …, 2011 - ASBMB
Desmosomes and adherens junctions are cadherin-based protein complexes responsible
for cell-cell adhesion of epithelial cells. Type 1 cadherins of adherens junctions show
specific homophilic adhesion that plays a major role in developmental tissue segregation.
The desmosomal cadherins, desmocollin and desmoglein, occur as several different
isoforms with overlapping expression in some tissues where different isoforms are located in
the same desmosomes. Although adhesive binding of desmosomal cadherins has been …
for cell-cell adhesion of epithelial cells. Type 1 cadherins of adherens junctions show
specific homophilic adhesion that plays a major role in developmental tissue segregation.
The desmosomal cadherins, desmocollin and desmoglein, occur as several different
isoforms with overlapping expression in some tissues where different isoforms are located in
the same desmosomes. Although adhesive binding of desmosomal cadherins has been …