Giant cell tumor of bone
RE Turcotte - Orthopedic Clinics, 2006 - orthopedic.theclinics.com
Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor that usually involves
the end of long bone. Its histogenesis remains unclear. It is characterized by a proliferation
of mononuclear stromal cells and the presence of many multinucleated giant cells with
homogenous distribution. The name giant cell tumor was suggested by Cooper and Travers
[1] in 1818. Virchow [2] suggested a malignant potential in 1846. Nélaton [3], a French
doctor, was the first to recognize the similarities of the multinucleated giant cell with …
the end of long bone. Its histogenesis remains unclear. It is characterized by a proliferation
of mononuclear stromal cells and the presence of many multinucleated giant cells with
homogenous distribution. The name giant cell tumor was suggested by Cooper and Travers
[1] in 1818. Virchow [2] suggested a malignant potential in 1846. Nélaton [3], a French
doctor, was the first to recognize the similarities of the multinucleated giant cell with …