[PDF][PDF] Skin barrier function in healthy subjects and patients with atopic dermatitis in relation to filaggrin loss-of-function mutations

I Jakasa, ES Koster, F Calkoen, WHI McLean… - Journal of investigative …, 2011 - core.ac.uk
I Jakasa, ES Koster, F Calkoen, WHI McLean, LE Campbell, JD Bos, MM Verberk, S Kezic
Journal of investigative dermatology, 2011core.ac.uk
2008; Jensen et al., 2009). Various causes for the impaired barrier in AD have been
suggested, including an aberrant composition and structure of the intercellular lipid bilayers
and an altered expression of the cornified envelope and keratinocyte structural proteins
(Proksch et al., 2008). Furthermore, barrier function in nonaffected skin has been shown to
be dependent on disease activity (Chamlin et al.,
2008; Jensen et al., 2009). Various causes for the impaired barrier in AD have been suggested, including an aberrant composition and structure of the intercellular lipid bilayers and an altered expression of the cornified envelope and keratinocyte structural proteins (Proksch et al., 2008). Furthermore, barrier function in nonaffected skin has been shown to be dependent on disease activity (Chamlin et al.,
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