Morris water maze test for learning and memory deficits in Alzheimer's disease model mice
K Bromley-Brits, Y Deng, W Song - JoVE (Journal of Visualized …, 2011 - jove.com
The Morris Water Maze (MWM) was first established by neuroscientist Richard G. Morris in
1981 in order to test hippocampal-dependent learning, including acquisition of spatial
memoryand long-term spatial memory 1. The MWM is a relatively simple procedure typically
consisting of six day trials, the main advantage being the differentiation between the spatial
(hidden-platform) and non-spatial (visible platform) conditions 2-4. In addition, the MWM
testing environment reduces odor trail interference 5. This has led the task to be used …
1981 in order to test hippocampal-dependent learning, including acquisition of spatial
memoryand long-term spatial memory 1. The MWM is a relatively simple procedure typically
consisting of six day trials, the main advantage being the differentiation between the spatial
(hidden-platform) and non-spatial (visible platform) conditions 2-4. In addition, the MWM
testing environment reduces odor trail interference 5. This has led the task to be used …