Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments
K Ishiguro, A Shiratsuchi, S Sato, A Omori… - FEBS …, 1993 - Wiley Online Library
K Ishiguro, A Shiratsuchi, S Sato, A Omori, M Arioka, S Kobayashi, T Uchida, K Imahori
FEBS letters, 1993•Wiley Online LibraryWe previously reported that tau protein kinase I (TPKI) induced normal tau protein into a
state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis
using several antibodies. We also present the amino acid sequence of TPKI, which is
identical to glycogen synthase kinase 3β (GSK3β). Moreover, we found that TPKI activity
was inseparable from GSK3 activity throughout the purification procedure. These results
indicate that TPKI is identical to GSK3β.
state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis
using several antibodies. We also present the amino acid sequence of TPKI, which is
identical to glycogen synthase kinase 3β (GSK3β). Moreover, we found that TPKI activity
was inseparable from GSK3 activity throughout the purification procedure. These results
indicate that TPKI is identical to GSK3β.
We previously reported that tau protein kinase I (TPKI) induced normal tau protein into a state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis using several antibodies. We also present the amino acid sequence of TPKI, which is identical to glycogen synthase kinase 3β (GSK3β). Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3β.
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