Hypoxic vasoconstriction in buffer-perfused rabbit lungs
N Weissmann, F Grimminger, D Walmrath… - Respiration physiology, 1995 - Elsevier
Isolated rabbit lungs were buffer-perfused under constant flow-conditions with separate
control of alveolar (PAO2) and mixed venous (PV̄O2) O2 tension. Alveolar hypoxia caused
an increase in pulmonary artery pressure (PAP) with sigmoidal dose-dependency.
Erythrocytes increased the strength of the hypoxic pulmonary vasoconstriction (HPV). The
contractile and vasorelaxant responses to the onset and release of alveolar hypoxia,
respectively, occurred within seconds. Kinetics of the PAP increase, but not the magnitude of …
control of alveolar (PAO2) and mixed venous (PV̄O2) O2 tension. Alveolar hypoxia caused
an increase in pulmonary artery pressure (PAP) with sigmoidal dose-dependency.
Erythrocytes increased the strength of the hypoxic pulmonary vasoconstriction (HPV). The
contractile and vasorelaxant responses to the onset and release of alveolar hypoxia,
respectively, occurred within seconds. Kinetics of the PAP increase, but not the magnitude of …