Long-term results after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: the ASTAMI randomised, controlled study
JO Beitnes, E Hopp, K Lunde, S Solheim, H Arnesen… - Heart, 2009 - heart.bmj.com
JO Beitnes, E Hopp, K Lunde, S Solheim, H Arnesen, JE Brinchmann, K Forfang, S Aakhus
Heart, 2009•heart.bmj.comObjective: To investigate long-term safety and efficacy after intracoronary injection of
autologous mononuclear bone marrow cells (mBMCs) in acute myocardial infarction (AMI).
Design: Randomised, controlled trial. Setting: Two university hospitals in Oslo, Norway.
Patients: Patients from the Autologous Stem cell Transplantation in Acute Myocardial
Infarction (ASTAMI) study were re-assessed 3 years after inclusion. Interventions: 100
patients with anterior wall ST-elevation myocardial infarction treated with acute …
autologous mononuclear bone marrow cells (mBMCs) in acute myocardial infarction (AMI).
Design: Randomised, controlled trial. Setting: Two university hospitals in Oslo, Norway.
Patients: Patients from the Autologous Stem cell Transplantation in Acute Myocardial
Infarction (ASTAMI) study were re-assessed 3 years after inclusion. Interventions: 100
patients with anterior wall ST-elevation myocardial infarction treated with acute …
Objective
To investigate long-term safety and efficacy after intracoronary injection of autologous mononuclear bone marrow cells (mBMCs) in acute myocardial infarction (AMI).
Design
Randomised, controlled trial.
Setting
Two university hospitals in Oslo, Norway.
Patients
Patients from the Autologous Stem cell Transplantation in Acute Myocardial Infarction (ASTAMI) study were re-assessed 3 years after inclusion.
Interventions
100 patients with anterior wall ST-elevation myocardial infarction treated with acute percutaneous coronary intervention (PCI) were randomised to receive intracoronary injection of mBMCs (n = 50) or not (n = 50).
Main outcome measures
Change in left ventricular (LV) ejection fraction (primary). Change in exercise capacity (peak VO2) and quality of life (secondary). Infarct size (additional aim), and safety.
Results
The rates of adverse clinical events in the groups were low and equal. There were no significant differences between groups in change of global LV systolic function by echocardiography or magnetic resonance imaging (MRI) during the follow-up. On exercise testing, the mBMC-treated patients had larger improvement in exercise time from 2–3 weeks to 3 years (1.5 minutes vs 0.6 minutes, p = 0.05), but the change in peak oxygen consumption did not differ (3.0 ml/kg/min vs 3.1 ml/kg/min, p = 0.75).
Conclusion
The results indicate that intracoronary mBMC treatment in AMI is safe in the long term. A small improvement in exercise time in the mBMC group was found, but no other effects of treatment could be identified 3 years after cell therapy.
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