Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice
D Chiabrando, V Fiorito, S Marro, L Silengo… - Blood Cells, Molecules …, 2013 - Elsevier
Ferroportin (FPN), the sole characterized iron exporter, is mainly controlled by the peptide
hormone hepcidin in response to iron, erythroid factors, hypoxia, and inflammation. In
addition, intracellular iron level controls FPN translation by modulating the binding of Iron
Responsive Proteins at the 5′ UTR of FPN mRNA. Recently, hypoxia inducible factor (HIF)
2α has been shown to regulate FPN expression in intestinal cells. Here we show that, during
experimentally-induced acute anemia in mice, FPN is regulated at transcriptional level in a …
hormone hepcidin in response to iron, erythroid factors, hypoxia, and inflammation. In
addition, intracellular iron level controls FPN translation by modulating the binding of Iron
Responsive Proteins at the 5′ UTR of FPN mRNA. Recently, hypoxia inducible factor (HIF)
2α has been shown to regulate FPN expression in intestinal cells. Here we show that, during
experimentally-induced acute anemia in mice, FPN is regulated at transcriptional level in a …