Gene therapy expressing amino-terminal truncated monocyte chemoattractant protein-1 prevents renal ischemia-reperfusion injury
K Furuichi, T Wada, Y Iwata, K Kitagawa… - Journal of the …, 2003 - journals.lww.com
Ischemia-reperfusion is closely associated with tissue damage in various organs, including
kidney. Despite clinical investigations, useful therapy for renal ischemia-reperfusion injury is
not available so far. This study evaluated therapeutic effects of gene therapy expressing an
amino-terminal deletion mutant of MCP-1 called 7ND to inhibit monocyte chemoattractant
protein (MCP)-1/CCR2 signaling in vivo on renal ischemia-reperfusion injury. 7ND gene
was transferred into the femoral muscle of Balb/c mice. Renal artery and vein of the left …
kidney. Despite clinical investigations, useful therapy for renal ischemia-reperfusion injury is
not available so far. This study evaluated therapeutic effects of gene therapy expressing an
amino-terminal deletion mutant of MCP-1 called 7ND to inhibit monocyte chemoattractant
protein (MCP)-1/CCR2 signaling in vivo on renal ischemia-reperfusion injury. 7ND gene
was transferred into the femoral muscle of Balb/c mice. Renal artery and vein of the left …