Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl) oxy) benzyl) pyrimidine-2, 4-diamine (GW2580) in normal and arthritic rats
JG Conway, H Pink, ML Bergquist, B Han… - The Journal of …, 2008 - Elsevier
The cFMS (cellular homolog of the V-FMS oncogene product of the Susan McDonough
strain of feline sarcoma virus)(Proc Natl Acad Sci USA 83: 3331–3335, 1986) kinase
inhibitor 5-(3-methoxy-4-((4-methoxybenzyl) oxy) benzyl) pyrimidine-2, 4-diamine (GW2580)
inhibits colony-stimulating factor (CSF)-1-induced monocyte growth and bone degradation
in vitro and inhibits CSF-1 signaling through cFMS kinase in 4-day models in mice (Proc Natl
Acad Sci USA 102: 16078, 2005). In the present study, the kinase selectivity of GW2580 was …
strain of feline sarcoma virus)(Proc Natl Acad Sci USA 83: 3331–3335, 1986) kinase
inhibitor 5-(3-methoxy-4-((4-methoxybenzyl) oxy) benzyl) pyrimidine-2, 4-diamine (GW2580)
inhibits colony-stimulating factor (CSF)-1-induced monocyte growth and bone degradation
in vitro and inhibits CSF-1 signaling through cFMS kinase in 4-day models in mice (Proc Natl
Acad Sci USA 102: 16078, 2005). In the present study, the kinase selectivity of GW2580 was …