Prevention of experimental choroidal neovascularization with intravitreal anti–vascular endothelial growth factor antibody fragment

MG Krzystolik, MA Afshari, AP Adamis… - Archives of …, 2002 - jamanetwork.com
Objective To evaluate the safety and efficacy of intravitreal injections of an antigen-binding
fragment of a recombinant humanized monoclonal antibody directed toward vascular
endothelial growth factor (rhuFab VEGF) in a monkey model of choroidal neovascularization
(CNV). Methods In phase 1 of the study, each animal received intravitreal injections, 500 µg
per eye, of rhuFab VEGF in one eye (prevention eye), while the contralateral eye received
rhuFab VEGF vehicle (control eye) at 2-week intervals. On day 21, laser photocoagulation …