[HTML][HTML] PPARδ is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction
K Ravnskjaer, F Frigerio, M Boergesen, T Nielsen… - Journal of lipid …, 2010 - ASBMB
The peroxisome proliferator-activated receptor δ (PPARδ) is implicated in regulation of
mitochondrial processes in a number of tissues, and PPARδ activation is associated with
decreased susceptibility to ectopic lipid deposition and metabolic disease. Here, we show
that PPARδ is the PPAR subtype expressed at the highest level in insulinoma cells and rat
pancreatic islets. Furthermore, PPARδ displays high transcriptional activity and acts in
pronounced synergy with retinoid-X-receptor (RXR). Interestingly, unsaturated fatty acids …
mitochondrial processes in a number of tissues, and PPARδ activation is associated with
decreased susceptibility to ectopic lipid deposition and metabolic disease. Here, we show
that PPARδ is the PPAR subtype expressed at the highest level in insulinoma cells and rat
pancreatic islets. Furthermore, PPARδ displays high transcriptional activity and acts in
pronounced synergy with retinoid-X-receptor (RXR). Interestingly, unsaturated fatty acids …
