Kisspeptins and the control of gonadotropin secretion in male and female rodents
J Roa, JM Castellano, VM Navarro, DJ Handelsman… - Peptides, 2009 - Elsevier
Kisspeptins, the products of KiSS-1 gene acting via G protein-coupled receptor 54 (GPR54),
have recently emerged as fundamental gatekeepers of gonadal function by virtue of their
ability to stimulate gonadotropin secretion. Indeed, since the original disclosure of the
reproductive facet of the KiSS-1/GPR54 system, an ever-growing number of studies have
substantiated the extraordinary potency of kisspeptins to elicit gonadotropin secretion in
different mammalian species, under different physiologic and experimental conditions, and …
have recently emerged as fundamental gatekeepers of gonadal function by virtue of their
ability to stimulate gonadotropin secretion. Indeed, since the original disclosure of the
reproductive facet of the KiSS-1/GPR54 system, an ever-growing number of studies have
substantiated the extraordinary potency of kisspeptins to elicit gonadotropin secretion in
different mammalian species, under different physiologic and experimental conditions, and …