Regulation and function of NF-κB transcription factors in the immune system
S Vallabhapurapu, M Karin - Annual review of immunology, 2009 - annualreviews.org
The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central
role in the immune system by regulating several processes ranging from the development
and survival of lymphocytes and lymphoid organs to the control of immune responses and
malignant transformation. The five members of the NF-κB family are normally kept inactive in
the cytoplasm by interaction with inhibitors called IκBs or the unprocessed forms of NF-κB1 …
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central
role in the immune system by regulating several processes ranging from the development
and survival of lymphocytes and lymphoid organs to the control of immune responses and
malignant transformation. The five members of the NF-κB family are normally kept inactive in
the cytoplasm by interaction with inhibitors called IκBs or the unprocessed forms of NF-κB1 …
