Objective To identify and characterize biochemical alterations in the retinas of very low-
density lipoprotein receptor (VLDLr) knockout mice in an animal model of retinal
angiomatous proliferation. Methods Immunohistochemical analysis, Western blot analysis,
reverse transcriptase–polymerase chain reaction, and electrophoretic mobility shift assay
were used to identify and characterize the altered gene and protein expression as well as
signal cascades involved in the pathogenesis of neovascularization in the retinas of VLDLr …