Genomic response of hypoxic Müller cells involves the very low density lipoprotein receptor as part of an angiogenic network

N Loewen, J Chen, VJ Dudley, VP Sarthy… - Experimental eye …, 2009 - Elsevier
Müller cells have recently been found to produce select angiogenic substances. In choosing
a more comprehensive approach, we wanted to study the genomic response of Müller cells
to hypoxia to identify novel angiogenic genes. An established Müller cell line (rMC-1) was
exposed to standard or hypoxic conditions. We analyzed gene expression with three
independent microarrays and determined differential expression levels compared to
normoxia. Selected genes were confirmed by real-time PCR (RTPCR). Subcellular …