[HTML][HTML] Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling
MR Frey, A Golovin, DB Polk - Journal of Biological Chemistry, 2004 - ASBMB
Members of the epidermal growth factor (EGF) family of ligands and their receptors regulate
migration and growth of intestinal epithelial cells. However, our understanding of the signal
transduction pathways determining these responses is incomplete. In this study we tested
the hypothesis that p38 is required for EGF-stimulated intestinal epithelial monolayer
restitution. EGF-stimulated migration in a wound closure model required continuous
presence of ligand for several hours for maximal response, suggesting a requirement for …
migration and growth of intestinal epithelial cells. However, our understanding of the signal
transduction pathways determining these responses is incomplete. In this study we tested
the hypothesis that p38 is required for EGF-stimulated intestinal epithelial monolayer
restitution. EGF-stimulated migration in a wound closure model required continuous
presence of ligand for several hours for maximal response, suggesting a requirement for …