Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner
Mixed background SHP−/− mice are resistant to diet-induced obesity due to increased
energy expenditure caused by enhanced PGC-1α expression in brown adipocytes.
However, congenic SHP−/− mice on the C57BL/6 background showed normal expression of
PGC-1α and other genes involved in brown adipose tissue thermogenesis. Thus, we
reinvestigated the impact of small heterodimer partner (SHP) deletion on diet-induced
obesity and insulin resistance using congenic SHP−/− mice. Compared with their C57BL/6 …
energy expenditure caused by enhanced PGC-1α expression in brown adipocytes.
However, congenic SHP−/− mice on the C57BL/6 background showed normal expression of
PGC-1α and other genes involved in brown adipose tissue thermogenesis. Thus, we
reinvestigated the impact of small heterodimer partner (SHP) deletion on diet-induced
obesity and insulin resistance using congenic SHP−/− mice. Compared with their C57BL/6 …
