A trial of antioxidants N-acetylcysteine and procysteine in ARDS
GR Bernard, AP Wheeler, MM Arons, PE Morris… - Chest, 1997 - Elsevier
Objective To determine the levels of glutathione and cysteine in patients with ARDS and
examine the effect of treatment with N-acetylcysteine (NAC) and L-2-oxothiazolidine-4-
carboxylate (Procysteine; Clintec Technologies Inc; Chicago [OTZ]) on these levels and on
common physiologic abnormalities, and organ dysfunction associated with ARDS. Design
Randomized, double-blind, placebo-controlled, prospective clinical trial. Setting ICUs in five
clinical centers in the United States and Canada. Patients Patients meeting a predetermined …
examine the effect of treatment with N-acetylcysteine (NAC) and L-2-oxothiazolidine-4-
carboxylate (Procysteine; Clintec Technologies Inc; Chicago [OTZ]) on these levels and on
common physiologic abnormalities, and organ dysfunction associated with ARDS. Design
Randomized, double-blind, placebo-controlled, prospective clinical trial. Setting ICUs in five
clinical centers in the United States and Canada. Patients Patients meeting a predetermined …