[HTML][HTML] β1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/protein kinase B signaling pathway
B Tian, K Lessan, J Kahm, J Kleidon… - Journal of Biological …, 2002 - ASBMB
Integrins regulate cell viability through their interaction with the extracellular matrix. Integrins
can sense mechanical forces arising from the matrix and convert these stimuli to chemical
signals capable of modulating intracellular signal transduction. The phosphatidylinositol 3-
kinase (PI3K)/Akt signaling pathway is a major regulator of cell survival. It is not known,
however, whether integrins, acting as mechanoreceptors, regulate cell survival via the
PI3K/Akt pathway. Here, we show that in response to a matrix-derived mechanical stimulus …
can sense mechanical forces arising from the matrix and convert these stimuli to chemical
signals capable of modulating intracellular signal transduction. The phosphatidylinositol 3-
kinase (PI3K)/Akt signaling pathway is a major regulator of cell survival. It is not known,
however, whether integrins, acting as mechanoreceptors, regulate cell survival via the
PI3K/Akt pathway. Here, we show that in response to a matrix-derived mechanical stimulus …