Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis
DM Gross, T Forsthuber, M Tary-Lehmann, C Etling… - Science, 1998 - science.org
DM Gross, T Forsthuber, M Tary-Lehmann, C Etling, K Ito, ZA Nagy, JA Field, AC Steere…
Science, 1998•science.orgTreatment-resistant Lyme arthritis is associated with immune reactivity to outer surface
protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major
histocompatibility complex class II allele DRB1* 0401. The immunodominant epitope of
OspA for T helper cells was identified. A homology search revealed a peptide from human
leukocyte function–associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals
with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to …
protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major
histocompatibility complex class II allele DRB1* 0401. The immunodominant epitope of
OspA for T helper cells was identified. A homology search revealed a peptide from human
leukocyte function–associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals
with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to …
Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401. The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function–associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.
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