The existence of cancer stem cells (CSCs) or stem-like cancer cells (SLCCs) is regarded as
the cause of tumor formation and recurrence. However, the origin of such cells remains
controversial with two competing hypotheses: CSCs are either transformed from tissue adult
stem cells or dedifferentiated from transformed progenitor cells. Compelling evidence has
determined the chromosomal aneuploidy to be one of the hallmarks of cancer cells,
indicating genome instability plays an important role in tumorigenesis, for which CSCs are …