New insights into mTOR signaling: mTORC2 and beyond
DR Alessi, LR Pearce, JM García-Martínez - Science signaling, 2009 - science.org
DR Alessi, LR Pearce, JM García-Martínez
Science signaling, 2009•science.orgThe mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating
cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid–
induced protein kinase (SGK). This mTOR complex also promotes the constitutive
phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and
protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by
promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the …
cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid–
induced protein kinase (SGK). This mTOR complex also promotes the constitutive
phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and
protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by
promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the …
The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid–induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.
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