[HTML][HTML] Cell signaling by receptor tyrosine kinases

J Schlessinger - Cell, 2000 - cell.com
Cell, 2000cell.com
A large group of genes in all eukaryotes encode for proteins that function as membrane
spanning cell surface receptors. Membrane receptors can be classified into distinct families
based upon the ligands they recognize, the biological responses they induce and, more
recently, according to their primary structures. A great variety of ligands bind to and regulate
the activity of cell surface receptors, including small organic molecules, lipids,
carbohydrates, peptides, and proteins. One large family of cell surface receptors is endowed …
A large group of genes in all eukaryotes encode for proteins that function as membrane spanning cell surface receptors. Membrane receptors can be classified into distinct families based upon the ligands they recognize, the biological responses they induce and, more recently, according to their primary structures. A great variety of ligands bind to and regulate the activity of cell surface receptors, including small organic molecules, lipids, carbohydrates, peptides, and proteins. One large family of cell surface receptors is endowed with intrinsic protein tyrosine kinase activity. These receptor tyrosine kinases (RTKs) catalyze transfer of the γ phosphate of ATP to hydroxyl groups of tyrosines on target proteins (
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