[HTML][HTML] Fibroblast growth factors

DM Ornitz, N Itoh - Genome biology, 2001 - Springer
DM Ornitz, N Itoh
Genome biology, 2001Springer
Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that
are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members
of the FGF family range in molecular mass from 17 to 34 kDa and share 13-71% amino acid
identity. Between vertebrate species, FGFs are highly conserved in both gene structure and
amino-acid sequence. FGFs have a high affinity for heparan sulfate proteoglycans and
require heparan sulfate to activate one of four cell-surface FGF receptors. During embryonic …
Summary
Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members of the FGF family range in molecular mass from 17 to 34 kDa and share 13-71% amino acid identity. Between vertebrate species, FGFs are highly conserved in both gene structure and amino-acid sequence. FGFs have a high affinity for heparan sulfate proteoglycans and require heparan sulfate to activate one of four cell-surface FGF receptors. During embryonic development, FGFs have diverse roles in regulating cell proliferation, migration and differentiation. In the adult organism, FGFs are homeostatic factors and function in tissue repair and response to injury. When inappropriately expressed, some FGFs can contribute to the pathogenesis of cancer. A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems.
Springer