Cutting edge: conventional CD8α+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1

CM Smith, GT Belz, NS Wilson… - The Journal of …, 2003 - journals.aai.org
CM Smith, GT Belz, NS Wilson, JA Villadangos, K Shortman, FR Carbone, WR Heath
The Journal of Immunology, 2003journals.aai.org
CTL play a major role in immunity to HSV type 1, but little is known about the priming
process. In this study, we have examined the class I-restricted presentation of an
immunodominant determinant from HSV-1 glycoprotein B after footpad infection. We have
found that the only cell types capable of presenting this determinant in draining popliteal
lymph nodes within the first 3 days after infection are the CD11c+ CD8α+ CD45RA−
dendritic cells. Given that such class I-restricted presentation is essential for CTL priming …
Abstract
CTL play a major role in immunity to HSV type 1, but little is known about the priming process. In this study, we have examined the class I-restricted presentation of an immunodominant determinant from HSV-1 glycoprotein B after footpad infection. We have found that the only cell types capable of presenting this determinant in draining popliteal lymph nodes within the first 3 days after infection are the CD11c+ CD8α+ CD45RA− dendritic cells. Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8α+ dendritic cells are the key subset involved in CTL immunity to this virus.
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