Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

S Bedoui, PG Whitney, J Waithman, L Eidsmo… - Nature …, 2009 - nature.com
S Bedoui, PG Whitney, J Waithman, L Eidsmo, L Wakim, I Caminschi, RS Allan, M Wojtasiak…
Nature immunology, 2009nature.com
Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a
langerin-positive CD103+ dermal subset. We examined their involvement in the
presentation of skin-associated viral and self antigens. Only the CD103+ subset efficiently
presented antigens of herpes simplex virus type 1 to naive CD8+ T cells, although all
subsets presented these antigens to CD4+ T cells. This showed that CD103+ DCs were the
migratory subset most efficient at processing viral antigens into the major histocompatibility …
Abstract
Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103+ dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens. Only the CD103+ subset efficiently presented antigens of herpes simplex virus type 1 to naive CD8+ T cells, although all subsets presented these antigens to CD4+ T cells. This showed that CD103+ DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation. This was supported by data showing only CD103+ DCs efficiently cross-presented skin-derived self antigens. This indicates CD103+ DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs.
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