[HTML][HTML] CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes

C Huysamen, JA Willment, KM Dennehy… - Journal of Biological …, 2008 - ASBMB
We describe here the first characterization of CLEC9A, a group V C-type lectin-like receptor
located in the" Dectin-1 cluster" of related receptors, which are encoded within the natural
killer (NK)-gene complex. Expression of human CLEC9A is highly restricted in peripheral
blood, being detected only on BDCA3+ dendritic cells and on a small subset of CD14+
CD16-monocytes. CLEC9A is expressed at the cell surface as a glycosylated dimer and can
mediate endocytosis, but not phagocytosis. CLEC9A possesses a cytoplasmic …