Steroid receptor RNA activator–a nuclear receptor coregulator with multiple partners: insights and challenges

SM Colley, PJ Leedman - Biochimie, 2011 - Elsevier
Steroid Receptor RNA Activator (SRA) occupies a unique and enigmatic position within the
nuclear receptor (NR) field and more broadly in transcriptional regulation. This is as a result
of its transcripts having both coding and non-coding coactivator activities along with its
protein product SRAP performing mixed coactivator/repressor functions. Recent publications
have provided greater understanding of SRA gene product activities and how they affect not
only NR function, but now more broadly, signalling pathways involved in differentiation and …