Alternative splicing of human insulin receptor messenger RNA
S Seino, GI Bell - Biochemical and biophysical research communications, 1989 - Elsevier
S Seino, GI Bell
Biochemical and biophysical research communications, 1989•ElsevierThe polymerase chain reaction has been used to examine alternative splicing of human
insulin receptor (hINSR) mRNA. Alternative splicing of a 36 base pair exon, exon 11,
generates hINSR transcripts encoding receptor isoforms which differ in sequence at the C-
terminal end of the insulin-binding α-subunit. This process appears to be tissue-specific and,
in addition, may be developmentally regulated.
insulin receptor (hINSR) mRNA. Alternative splicing of a 36 base pair exon, exon 11,
generates hINSR transcripts encoding receptor isoforms which differ in sequence at the C-
terminal end of the insulin-binding α-subunit. This process appears to be tissue-specific and,
in addition, may be developmentally regulated.
Abstract
The polymerase chain reaction has been used to examine alternative splicing of human insulin receptor (hINSR) mRNA. Alternative splicing of a 36 base pair exon, exon 11, generates hINSR transcripts encoding receptor isoforms which differ in sequence at the C-terminal end of the insulin-binding α-subunit. This process appears to be tissue-specific and, in addition, may be developmentally regulated.
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