The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
E Karran, M Mercken, BD Strooper - Nature reviews Drug discovery, 2011 - nature.com
E Karran, M Mercken, BD Strooper
Nature reviews Drug discovery, 2011•nature.comThe amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide
in the brain is a central event in Alzheimer's disease pathology, has dominated research for
the past twenty years. Several therapeutics that were purported to reduce amyloid-β
production or aggregation have failed in Phase III clinical testing, and many others are in
various stages of development. Therefore, it is timely to review the science underpinning the
amyloid cascade hypothesis, consider what type of clinical trials will constitute a valid test of …
in the brain is a central event in Alzheimer's disease pathology, has dominated research for
the past twenty years. Several therapeutics that were purported to reduce amyloid-β
production or aggregation have failed in Phase III clinical testing, and many others are in
various stages of development. Therefore, it is timely to review the science underpinning the
amyloid cascade hypothesis, consider what type of clinical trials will constitute a valid test of …
Abstract
The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide in the brain is a central event in Alzheimer's disease pathology, has dominated research for the past twenty years. Several therapeutics that were purported to reduce amyloid-β production or aggregation have failed in Phase III clinical testing, and many others are in various stages of development. Therefore, it is timely to review the science underpinning the amyloid cascade hypothesis, consider what type of clinical trials will constitute a valid test of this hypothesis and explore whether amyloid-β-directed therapeutics will provide the medicines that are urgently needed by society for treating this devastating disease.
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