Versican is a large chondroitin sulfate proteoglycan of the extracellular matrix that is
involved in a variety of cellular processes. We showed previously that versican, which is
overexpressed in cutaneous melanomas as well as in premalignant lesions, contributes to
melanoma progression, favoring the detachment of cells and the metastatic dissemination.
Here, we investigated the transcriptional regulation of the versican promoter in melanoma
cell lines with different levels of biological aggressiveness and stages of differentiation. We …