The cell fate determination factor Dachshund was cloned as a dominant inhibitor of the
hyperactive epidermal growth factor receptor ellipse. The expression of Dachshund is lost in
human breast cancer associated with poor prognosis. Breast tumor-initiating cells (TIC) may
contribute to tumor progression and therapy resistance. Here, endogenous DACH1 was
reduced in breast cancer cell lines with high expression of TIC markers and in patient
samples of the basal breast cancer phenotype. Re-expression of DACH1 reduced new …