Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

C Wang, Z Li, Y Lu, R Du, S Katiyar… - Proceedings of the …, 2006 - National Acad Sciences
C Wang, Z Li, Y Lu, R Du, S Katiyar, J Yang, M Fu, JE Leader, A Quong, PM Novikoff…
Proceedings of the National Academy of Sciences, 2006National Acad Sciences
Cyclin D1 promotes nuclear DNA synthesis through phosphorylation and inactivation of the
pRb tumor suppressor. Herein, cyclin D1 deficiency increased mitochondrial size and
activity that was rescued by cyclin D1 in a Cdk-dependent manner. Nuclear respiratory factor
1 (NRF-1), which induces nuclear-encoded mitochondrial genes, was repressed in
expression and activity by cyclin D1. Cyclin D1-dependent kinase phosphorylates NRF-1 at
S47. Cyclin D1 abundance thus coordinates nuclear DNA synthesis and mitochondrial …
Cyclin D1 promotes nuclear DNA synthesis through phosphorylation and inactivation of the pRb tumor suppressor. Herein, cyclin D1 deficiency increased mitochondrial size and activity that was rescued by cyclin D1 in a Cdk-dependent manner. Nuclear respiratory factor 1 (NRF-1), which induces nuclear-encoded mitochondrial genes, was repressed in expression and activity by cyclin D1. Cyclin D1-dependent kinase phosphorylates NRF-1 at S47. Cyclin D1 abundance thus coordinates nuclear DNA synthesis and mitochondrial function.
National Acad Sciences