Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes
LS Liu, GB Karkanias, M Jose'C, M Hawkins… - Journal of Biological …, 1998 - jbc.org
Acute intravenous infusions of leptin markedly alter hepatic glucose fluxes (Rossetti, L.,
Massillon, D., Barzilai, N., Vuguin, P., Chen, W., Hawkins, M., Wu, J., and Wang, J.(1997) J.
Biol. Chem. 272, 27758–22763). Here we examine whether intracerebroventricular (ICV)
leptin administration regulates peripheral and hepatic insulin action. Recombinant mouse
leptin (n= 14; 0.02 or 1 μg/kg· h) or vehicle (n= 9) were administered ICV for 6 h to conscious
rats, and insulin action was determined by insulin (3 milliunits/kg· min) clamp and tracer …
Massillon, D., Barzilai, N., Vuguin, P., Chen, W., Hawkins, M., Wu, J., and Wang, J.(1997) J.
Biol. Chem. 272, 27758–22763). Here we examine whether intracerebroventricular (ICV)
leptin administration regulates peripheral and hepatic insulin action. Recombinant mouse
leptin (n= 14; 0.02 or 1 μg/kg· h) or vehicle (n= 9) were administered ICV for 6 h to conscious
rats, and insulin action was determined by insulin (3 milliunits/kg· min) clamp and tracer …
