Acute myeloid leukemia (AML) is a heterogeneous group of leukemias that result from clonal
transformation of hematopoietic precursors through the acquisition of chromosomal
rearrangements and multiple gene mutations. As a result of highly collaborative clinical
research by pediatric cooperative cancer groups worldwide, disease-free survival has
improved significantly during the past 3 decades. Further improvements in outcomes of
children who have AML probably will reflect continued progress in understanding the …

Acute myeloid leukemia (AML) remains the most common form of acute leukemia among
adults and accounts for the largest number of annual deaths due to leukemias in the United
States. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for AML
provide recommendations on the diagnostic evaluation and workup for AML, risk
assessment based on cytogenetic and molecular features, treatment options for induction
and consolidation therapies for younger and older (age≥ 65 years) adult patients, and key …